# CureGraph — Full LLM & AI Agent Reference (curegraph.futuretranz.ai)

> Biomedical Evidence, Knowledge Graph, Hypothesis & Experiment Workspace by FutureTranz, Inc.

## 1. Platform Overview & Non-Clinical Research Guardrails
CureGraph (`https://curegraph.futuretranz.ai`) is a biomedical research-support workspace engineered by FutureTranz, Inc. (`FutureTranz-Inc/CureGraph`).
- **Mandatory Non-Clinical Guardrails**:
  - For research use by qualified biomedical professionals only. Not for clinical decision-making or medical advice.
  - Never recommends drugs, clinical treatments, or dosages.
  - Never fabricates citations; every claim must link to a verifiable PubMed PMID, PMC ID, DOI, or ClinicalTrials.gov NCT identifier.
  - Never claims correlation or association proves causation; evidence-confidence scores are transparent weighted rubrics, not probabilities of truth.
  - Rejects Protected Health Information (PHI) and patient-identifiable uploads.

## 2. 5-Stage Biomedical Research Pipeline
1. **Stage 1 — Literature & Trial Grounding**: Ingests and normalizes peer-reviewed PubMed/PMC papers (`PMID:36456789`, `PMID:37112233`, `PMID:35884412`, `PMID:34901122`, `PMID:38019283`) and ClinicalTrials.gov studies (`NCT05382559`, `NCT04667234`, `NCT05194930`, `NCT03825289`) with explicit sample sizes, study phases, and limitations.
2. **Stage 2 — Biological Knowledge Graph**: Maps genes (`KRAS`, `TP53`, `CDKN2A`, `SMAD4`, `BRCA2`, `MYC`), pathways (`MAPK/ERK`, `Autophagy`, `PI3K/AKT/mTOR`), phenotypes, and candidate assays with typed edges (`CO_MUTATED_WITH`, `ACTIVATES_PATHWAY`, `COMPENSATES_VIA`, `EVALUATED_IN_TRIAL`).
3. **Stage 3 — Hypothesis Generation & 5-Dimension Evidence-Confidence Scorer**: Scores candidate hypotheses across Replication, Sample Size, Mechanistic Plausibility, Model Relevance, and Contradiction Penalty, plus explicit Falsification Criteria.
4. **Stage 4 — Ethics-Gated Experiment Planner**: Enforces IRB/IACUC, Biosafety Level (BSL), and No-PHI verification gates before unlocking wet-lab or computational assay protocols.
5. **Stage 5 — Reproducible Citation-Backed Brief Export**: Exports structured Markdown/JSON research briefs with full provenance trails.

## 3. Programmatic AI Agent CTA (`POST /api/leads`)
Endpoint: `https://curegraph.futuretranz.ai/api/leads`
- Discovery: `GET https://curegraph.futuretranz.ai/api/leads`
- Execution: `POST https://curegraph.futuretranz.ai/api/leads` with `"agentMode": true`
- Telemetry: `GET https://curegraph.futuretranz.ai/api/status`
- Manifest: `GET https://curegraph.futuretranz.ai/.well-known/agent.json`